فهرست و منابع پایان نامه سنتز نانو ذرات مغناطیسی با پوشش طلا مزدوج شده با سیستامین به عنوان عامل انتقال دارو
فهرست:
فصل اول....................................................................................................................................................1
1-1 مقدمه.................................................................................................................................................2
1-2 نانو فناوری.........................................................................................................................................8
1-3 نانو ذرات.........................................................................................................................................10
1-4 طبقه بندی نانو ذرات.......................................................................................................................11
1-4-1 سوپر پارامغناطیس.......................................................................................................................11
1-4-2 نانو ذرات فلزی..........................................................................................................................12
1-4-3 نانو مواد سه بعدی.......................................................................................................................15
1-4-4 نانو مواد دو بعدی.......................................................................................................................15
1-4-5 نانو مواد تک بعدی......................................................................................................................16
1-4-6 نانو لوله ها...................................................................................................................................16
1-4-7 نانو میله های طلا .......................................................................................................................16
1-4-8 نانو سیم ها..................................................................................................................................18
1-4-9 نانو مواد صفر بعدی....................................................................................................................18
1-4-10 نقاط کوانتومی..........................................................................................................................18
1-4-11 نانو ذرات لپیدی......................................................................................................................19
1-4-12 نانو ذرات پلیمری....................................................................................................................20
1-5 نانو ذرات طلا................................................................................................................................21
1-6 خواص نوری نانو ذرات طلا..........................................................................................................23
1-7 انواع پلاسمون سطحی....................................................................................................................24
1-8 محاسبات کمی خواص نوری نانو ذرات طلا..................................................................................28
1-9 پارامترهای موثر در طراحی نانو ذرات مغناطیسی............................................................................32
1-9-1 موانع فیزیولوژیکی......................................................................................................................32
1-9-2 پارامترهای فیزیکی......................................................................................................................34
1-9-3 اندازه هیدرودینامیک..................................................................................................................34
1-10 مزایایی پوشش دار کردن سطح نانو ذرات.....................................................................................36
1-11 موانع در کاربردهای پزشکی..........................................................................................................37
1-12 نتیجه گیری....................................................................................................................................38
فصل دوم.........................................................................................................................40
2-1 سیستامین..........................................................................................................................................41
2-2 فاموتیدین.........................................................................................................................................42
2-3 مروری بر کارهای انجام گرفته.........................................................................................................42
2-3-1 توموگرافی محاسبه شده اشعه ایکس...........................................................................................48
2-3-2 حسی زیستی...............................................................................................................................50
2-4 مطالعه سمیت نانو ذرات مغناطیسی.................................................................................................52
فصل سوم................................................................................................................................................55
3-1 واکنشگر ها......................................................................................................................................56
3-2 تهییه محول ها..................................................................................................................................57
3-3 دستگاه ها.........................................................................................................................................57
3-4 روش تولید نانو ذره آهن.................................................................................................................58
3-5 روش پوشش دهی نانو ذره آهن با طلا............................................................................................60
3-6 در مجاورت قرار دادن سیستامین و نانو ذره....................................................................................61
3-7 روش محاسبه غلظت تقریبی نانو ذرات طلا....................................................................................61
فصل چهارم.............................................................................................................................................62
4-1 مقدمه..............................................................................................................................................63
4-2 طیف FT-IR از نانو ذره آهن.........................................................................................................64
4-3 تائید پوشش دهی نانو ذره آهن با طلا.............................................................................................65
4-4 قرار دادن نانو ذره آهن پوشش داده شده با طلا در مجاورت سیستامین..........................................66
4-5 تعیین زمان بهینه جذب....................................................................................................................66
4-5-1 تعیین زمان بهینه جذب 0.1 مولار سیستامین..............................................................................66
4-5-2 تعیین زمان بهینه جذب 0.5 مولار سیستامین.............................................................................67
4-5-3 تعیین زمان بهینه جذب 0.05 مولار سیستامین............................................................................68
4-6 تعیین غلظت بهینه جذب ...............................................................................................................69
4-7 تعیین pH بهینه جذب...................................................................................................................70
4-8 بررسی نتایج زمان بهینه جذب.........................................................................................................71
4-9 بررسی نتایج غلظت بهینه جذب......................................................................................................75
4-10 بررسی نتایج pH بهینه جذب........................................................................................................
[1] Xia,Y.; Halas,N.J.Shape.Contoroll Synthesisand Surface Plasmonic Propertes of Mentallic Nanostructures MRS Bulletin 30/2005 338-343
[2] Toshima .N;Yonnezawa. T.Bimetallic, Novel materials for chemical and physical application New.J chem. 22(1998) 1179-1185
[3]Agarwal A, Huang SW, O’Donnell M, et al. 2007. Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging.
[4]J Appl Phys, 102:064701–1.
Ahmed SM, Salgia R. 2006. Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer. Respirology,
11:687–92.
[5]Aime S, Botta M, Fasano M, et al. 1998. Lanthanide(III) chelates for NMR biomedical applications. Chem Soc Rev, 27:19.
[6]Akerman ME, Chan WCW, Laakkonen P, et al. 2002. Nanocrystal targeting
in vivo. Proc Natl Acad Sci U S A, 99:12617–21
.
[7]Allen TM, Hansen C, Martin F, et al. 1991. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta, 1066:29–36.
[8]Aubin ME, Morales DG, Hamad-Schifferli K. 2005. Labeling ribonucleas S with a 3 nm Au nanoparticle by two-step assembly Nano Lett, 5:519–22.
[9]Bakó J, Szepesi M, Márton I, et al. 2007. Synthesis of nanoparticles for dental drug delivery systems. Fogorvosi Szemle, 100:109–13.
[10]Ballou B, Lagerholm BC, Ernst LA, et al. 2004. Noninvasive imaging of quantum dots in mice Bioconjug Chem, 15:79–86
.
[11]Baron R, Willner B, Willner I. 2007. Biomolecule–nanoparticle hybrids as
functional units for nanobiotechnology. Chem Commun, 28:323–32.
[12]Bernardi RJ, Lowery AR, Thompson PA, et al. 2008. Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines. J Neurooncol, 86:165–72.
[13]Bhattacharya R, Patra CR, Earl A, et al. 2007. Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells. Nanomedicine, 3:224–38.
[14]Boyer D, Tamarat P, Maali A, et al. 2002. Photothermal imaging of nanometer-sized metal particles among scatterers. Science,297:1160–3.
[15]Brito L, Amiji M. 2007. Nanoparticulate carriers for the treatment of coronary restenosis. Int J Nanomedicine, 2:143–61.
Brouckaert PG, Leroux-Roels GG, Guisez Y, et al. 1986
[16]Brown KR, Natan MJ. 1998. Hydroxylamine seeding of colloidal Au nanoparticles in solution and on surfaces. Langmuir, 14:726–8.
[17]Bruchez M Jr, Moronne M, Gin P, et al. 1998. Semiconductor nanocrystals
as fl uorescent biological labels. Science, 281:2013–6.
[18]Busbee BD, Obare SO, Murphy CJ. 2003. An improved synthesis of highaspect- ratio gold nanorods. J Adv Mater, 15:414–6.
[19]Cao YC, Jin R, Mirkin CA. 2002. Nanoparticles with raman spectroscopic
fi ngerprints for DNA and RNA detection. Science, 297:1536–40.
[20]Caravan P, Ellison JJ, McMurry TJ, et al. 1999. Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications. Chem
Rev, 99:2293–352.
[21]Caravan P, Greenwood JM, Welch JT, et al. 2003. Gadolinium-binding helix–turn–helix peptides: DNA-dependent MRI contrast agents. Chem Commun, 20:2574–5.
[22]Caruso RA, Antonietti M. 2001. Sol-gel nanocoating: An approach to the preparation of structured materials. Chem Mater, 13:3272–82.
[23]Chah S, Hammond MR, Zare RN. 2005. Gold nanoparticles as a colorimetric sensor for protein conformational changes. Chem Biol,
12:323–8.
[24]Chan WC, Maxwell DJ, Gao X, et al. 2002. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol,13:40–6.
[25]Chen J, Saeki F, Wiley BJ, et al. 2005. Gold nanocages: bioconjugation
and their potential use as optical imaging contrast agents. Nano Lett,
5:473–7.
[26] Toshima .N:Yoneezawa.T.Bimetallic Novel materials for chemical and physical application New.J. chem. 22(1998)1179-1185
[27]Agarwal A, Huang SW, O’Donnell M, et al. 2007. Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging. J Appl Phys, 102:064701–1.
[28]Ahmed SM, Salgia R. 2006. Epidermal growth factor receptor mutations and susceptibility to targeted therapy in lung cancer. Respirology, 11:687–92.
[29]Aime S, Botta M, Fasano M, et al. 1998. Lanthanide(III) chelates for NMR biomedical applications. Chem Soc Rev, 27:19.
[30]Akerman ME, Chan WCW, Laakkonen P, et al. 2002. Nanocrystal targeting in vivo. Proc Natl Acad Sci U S A, 99:12617–21.
[31]Allen TM, Hansen C, Martin F, et al. 1991. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim Biophys Acta, 1066:29–36
.
[31]Arteaga CL. 2001. The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to terapeutic target in human neoplasia. J Clin Oncol, 19:32s–40s.
[32]Aubin ME, Morales DG, Hamad-Schifferli K. 2005. Labeling ribonuclease S with a 3 nm Au nanoparticle by two-step assembly Nano Lett, 5:519–22.
[33]Bakó J, Szepesi M, Márton I, et al. 2007. Synthesis of nanoparticles for dental drug delivery systems. Fogorvosi Szemle, 100:109–13.
[34]Ballou B, Lagerholm BC, Ernst LA, et al. 2004. Noninvasive imaging of quantum dots in mice Bioconjug Chem, 15:79–86.
[35]Baron R, Willner B, Willner I. 2007. Biomolecule–nanoparticle hybrids as functional units for nanobiotechnology. Chem Commun, 28:323–32
.
[36]Bernardi RJ, Lowery AR, Thompson PA, et al. 2008. Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines. J Neurooncol,
86:165–72.
[37]Bhattacharya R, Patra CR, Earl A, et al. 2007. Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells. Nanomedicine,
3:224–38.
[38]Boyer D, Tamarat P, Maali A, et al. 2002. Photothermal imaging of nanometer-sized metal particles among scatterers. Science,297:1160–3.
[39]Brito L, Amiji M. 2007. Nanoparticulate carriers for the treatment of coronary restenosis. Int J Nanomedicine, 2:143–61.
[40]Brouckaert PG, Leroux-Roels GG, Guisez Y, et al. 1986. In vivo antitumour activity of recombinant human and murine TNF, alone and in combination with murine IFN-, on a syngeneic murine melanoma. Int J Cancer, 38:763–9.
[41]Brown KR, Natan MJ. 1998. Hydroxylamine seeding of colloidal Au nanoparticles in solution and on surfaces. Langmuir, 14:726–8.
[42]Bruchez M Jr, Moronne M, Gin P, et al. 1998. Semiconductor nanocrystals as fl uorescent biological labels. Science, 281:2013–6.
[43]Busbee BD, Obare SO, Murphy CJ. 2003. An improved synthesis of highaspect- ratio gold nanorods. J Adv Mater, 15:414–6.
[44]Cao YC, Jin R, Mirkin CA. 2002. Nanoparticles with raman spectroscopic fi ngerprints for DNA and RNA detection. Science, 297:1536–40.
[45]Caravan P, Ellison JJ, McMurry TJ, et al. 1999. Gadolinium(III) chelates as MRI contrast agents: Structure, dynamics, and applications. Chem Rev, 99:2293–352.
[46] Caravan P, Greenwood JM, Welch JT, et al. 2003. Gadolinium-binding helix–turn–helix peptides: DNA-dependent MRI contrast agents. Chem Commun, 20:2574–5.
[47]Caruso RA, Antonietti M. 2001. Sol-gel nanocoating: An approach to the preparation of structured materials. Chem Mater, 13:3272–82
.
[48]Chah S, Hammond MR, Zare RN. 2005. Gold nanoparticles as a colorimetric sensor for protein conformational changes. Chem Biol, 12:323–8.
[49]Chan WC, Maxwell DJ, Gao X, et al. 2002. Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol,13:40–6.
[50]Chen J, Saeki F, Wiley BJ, et al. 2005. Gold nanocages: bioconjugation and their potential use as optical imaging contrast agents. Nano Lett, 5:473–7.
[51]Chen J, Wang D, Xi J, et al. 2007a. Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells Nano Lett, 7:1318–22.
[52]Chen Y, Tsai C, Huang P, et al. 2007b. Methotrexate conjugated to gold nanoparticles inhibits tumor growth in a syngeneic lung tumor model. Mol Pharm, 4:713–22.
[53]Cheng MM, Cuda G, Bunimovich YL, et al. 2006. Nanotechnologies for biomolecular detection and medical diagnostics. Curr Opin Chem Biol, 10:11–9.
[54]Cho K, Wang X, Nie S, et al. 2008. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res, 14:1310–6.
[55]Cognet L, Tardin C, Boyer D, et al. 2003. Single metallic nanoparticle imaging for protein detection in cells. Proc Natl Acad Sci U S A, 100:11350–5.
[56]Cohenuram M, Saif MW. 2007. Epidermal growth factor receptor inhibition strategies in pancreatic cancer: past, present and the future. J Pancreas, 8:4–15.
[57]Connor EE, Mwamuka J, Gole A, et al. 2005. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small, 1:325–7
.
[58]CytImmune. 2008. Aurimune™ (CYT-6091) [online]. Accessed on Sept 1, 2008. URL: http://www.cytimmune.com/go.cfm?do=Page.View&pid=26.
[59]de la Furente JM, Berry CC, Riehle MO, et al. 2006. Nanoparticle targeting at cells. Langmuir, 22:3286–93.
de la Furente JM, Berry CC. 2005. Tat peptide as an effi cient molecule to translocate gold nanoparticles into the cell nucleus. Bioconjug Chem, 16:1176–80.
[60]De M, You C-C, Srivastava S, et al. 2007. Biomimetic interactions of proteins with functionalized nanoparticles: a thermodynamic study. J Am Chem Soc, 129:10747–53.
[61]Debouttiere P-J, Roux S, Vocanson F, et al. 2006. Design of gold nanoparticles for magnetic resonance imaging. Adv Funct Mater, 16:2330–9.
[62]Demann ET, Stein PS, Haubenreich JE. 2005. Gold as an implant in medicine and dentistry. J Long Term Eff Med Implants, 15:687